WHAT IS DIPG?

Diffuse Intrinsic Pontine Gliomas (DIPGs) are the most lethal brain tumors afflicting children. The tumor grows inside the brain stem and is not resectable. Most patients succumb to their disease within a year of diagnosis and long term survival is less than 1%. Pediatric patients are currently treated with radiation therapy and often chemotherapy; however, tumors exhibit rapid resistance to these therapies and commonly start to grow again within months of treatment completion. Understanding the biology of DIPG is critical in order to identify new effective treatments for this disease.

While considerable progress has been made in the identification of molecular subtypes of many cancers, the transfer of these findings into improved therapies for children with DIPG has not yet been realized. Genetic studies of DIPG have recently shed light on their mutations, but much remains to be learned about how this tumor starts growing and maintains itself.

5-year survival rates of childhood cancer. DIPG has a 5-year survival rate of less than 1 percent.

HODGKIN LYMPHOMA
98%
RETINOBLASTOMA
97%
Wilms tumor
92%
Acute lymphocytitc leukemia
89%
Non-hodgkin lymphoma
89%
Overall
83%
Neuroblastoma
78%
Ewing sarcoma
78%
Osteosarcoma
69%
DIFFUSE INTRINSIC PONTINE GLIOMA (DIPG)
0.6%